Cholesterol metabolism during the growth of a rat ascites hepatoma (Yoshida AH-130)
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چکیده
منابع مشابه
Marked hyperlipidaemia in rats bearing the Yoshida AH-130 ascites hepatoma.
Malignant tumour burden is a pathological s ta te associated with a considerable demand for nutrients by the growing tumour [l]. Although a great deal of work has been carried out, there are contradictory results about the effects of tumour burden on lipid metabolism both in experimental animals and man. Lipid oxidation has been reported either increased [2], unchanged [3] or decreased [4]. In ...
متن کاملMetabolic-independent volume changes and Mg++ binding in mitochondria isolated from AH-130 Yoshida ascites hepatoma.
The mitochondria isolated in isotonic sucrose from AH-130 Yoshida ascites hepatoma appear spontaneously swollen (11, 12). This spontaneous swelling may be in part responsible for the inability of tumor mitochondria to undergo extensive volume changes in hypotonie conditions or in conditions that induce large-amplitude, metabolic-dependent, or metabolic-independent swelling in normal liver mitoc...
متن کاملAmiloride inhibits protein synthesis and lowers the intracellular pH in exponential growing Yoshida rat ascites hepatoma (AH 130) cells: evidence for a role of the Na+/H+ exchanger.
We have previously demonstrated in a rat ascites hepatoma cell line (Yoshida AH 130) the presence of a glucose-activatable and amiloride sensitive Na+/H+ exchange (Cell Biol. Int. Rep., 1984, 8, 297-307). Amiloride is known to inhibit this exchange and to cause a cytoplasmic acidification, with inhibition of protein and DNA synthesis, in cells induced to grow. Amiloride appears also to penetrat...
متن کاملApoptosis induced by clofibrate in Yoshida AH-130 hepatoma cells: role of HMG-CoA reductase.
Clofibrate is a hypolipidemic drug belonging to the peroxisome proliferator (PP) family. PPs are well-recognized hepatocarcinogens, though only for rodents and not for humans. Their oncogenicity is usually ascribed to mitogenic or antiapoptotic action. However, we have reported that clofibrate can trigger fast and extensive apoptosis in rodent and human tumor cell lines. The present study exami...
متن کاملSubmicroscopic structure of Yoshida ascites hepatoma.
The electron microscope study of u ascites hepatoma cells confirms their epithelial origin. Isolated cells may occur, but they are mostly gathered to form islets. Cell surfaces exhibit microvilli. Cells are interconnected by means of microvilli and of structures similar to the epithelial "terminal bars." The cells line spaces and canaliculi similar to bile canaliculi. The cytoplasm is poorly di...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1992
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1992.361